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本文探讨了重组α_2-干扰素(α_2-IF)对未经治疗的早期 B-CLL 的效果。受试者10例中有7例处于0期,3例处于Ⅰ期。给予α_2-IF2×10~6U/m~2,每周3次,肌肉注射。疗程持续14周以上。出现的副作用,10例受试者均出现了感冒样症状,并有不同程度的血色素及血小板的减少。但并未出现需要减少或停止给予α_2-IF 的病例。结果:10例患者均有末梢血淋巴细胞绝对数减少的情况(中间值18→9×10~9/L)。还观察到其中8例患者颗粒细胞绝对数增加。淋巴细胞从治疗开始后4～12周减少至最低点。
This article explored the effect of recombinant α_2-interferon (α_2-IF) on untreated early B-CLL. Of the 10 subjects, 7 were in stage 0 and 3 were in stage I. Give α_2-IF2 × 10 ~ 6U / m ~ 2, 3 times a week, intramuscular injection. Duration of 14 weeks or more. The side effects occurred, all 10 subjects had flu-like symptoms, with varying degrees of hemoglobin and platelet reduction. However, there was no indication of the need to reduce or discontinue administration of α_2-IF. Results: The absolute number of peripheral blood lymphocytes decreased in all 10 patients (median 18 → 9 × 10 ~ 9 / L). It was also observed that 8 of them had an increase in the absolute number of granulosa cells. Lymphocytes are reduced to their lowest point 4 to 12 weeks after the start of treatment.