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目的:评价环磷腺苷葡胺对慢性充血性心力衰竭的疗效及安全性。方法:将92例慢性充血性心力衰竭的患者随机分为两组,对照组(46例)采用常规治疗,治疗组(46例)采用常规治疗及静脉滴注环磷腺苷葡胺120mg,qd,10d为1个疗程,每月1个疗程,连续3个月。结果:治疗组临床总有效率93.5%,对照组总有效率73.9%。两组比较差异有统计学意义(P<0.05);用药3个月后治疗组左心室舒张末期内径、射血分数、心搏出量、短轴缩短分数及6min步行试验较对照组明显改善(P<0.05)。结论:在常规治疗基础上加用环磷腺苷葡胺,可进一步改善患者的心功能,提高运动耐量,且耐受性良好,未见不良反应。
Objective: To evaluate the efficacy and safety of cyclic adenosine diphosphate in chronic congestive heart failure. Methods: Ninety-two patients with chronic congestive heart failure were randomly divided into two groups. The control group (n = 46) received routine treatment. The treatment group (n = 46) received routine therapy and intravenous infusion of amiodarone , 10d for a course of treatment, a course of treatment per month for 3 consecutive months. Results: The total clinical effective rate was 93.5% in the treatment group and 73.9% in the control group. Compared with the control group, the left ventricular end-diastolic diameter, ejection fraction, cardiac output, short axis shortening score and 6-minute walk test in the treatment group were significantly improved after 3 months of treatment (P <0.05) P <0.05). Conclusion: The addition of cyclic adenosine diatrizoate on the basis of routine treatment can further improve the patient’s cardiac function, improve exercise tolerance, and is well tolerated, with no adverse reactions.