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胰岛素依赖型糖尿病(IDDA)是因胰岛β细胞障碍,内源性胰岛素绝对不足而引起。其原因为自身免疫机制障碍和在特定的遗传背景基础上,环境因素作用于个体而发病。本文概要介绍日本人的IDDM、人白细胞抗原(HLA)基因、胰腺自身抗体和相对应的抗原和自身免疫疾患合并症的特征及作者的经验。一、IDDM和HLA基因IDDM在一卵双生儿的一致发生率约占30～50%,高于约占10%的双卵双生儿,提示存在着基因的作用。具体说来,即与人主要组织适合性复合体(MHC)基固的HLA基因有关。该基因位于人第6位基因的
Insulin-dependent diabetes mellitus (IDDA) is caused by a lack of endogenous insulin due to islet beta-cell dysfunction. The reason for the obstacles of autoimmune mechanism and in a specific genetic background, based on environmental factors acting on the individual and disease. This article provides an overview of the characteristics of Japanese IDDM, human leukocyte antigen (HLA) genes, pancreatic autoantibodies and their associated antigenic and autoimmune disorders and the authors’ experience. First, IDDM and HLA gene IDDM consistent in a twins accounted for about 30 to 50%, higher than about 10% of the twins twins, suggesting the existence of the role of genes. Specifically, it is associated with HLA genes that are the backbone of human adaptive host (MHC) complexes. The gene is located in the human sixth gene