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胺碘酮具有抗肾上腺素能活性,能增加心脏能量储备,减少心肌耗氧量;兼有扩张冠状动脉、对抗α-和β-肾上腺素受体和抗心律失常的药理性能,在临床上广泛用于治疗和预防室性和室上性心律失常。但胺碘酮可引起甲状腺激素合成与分泌的暂时性减少,抑制T_4在外周组织转化为T_3的过程,提高外周组织靶细胞对甲状腺激素作用的抵抗性。长期使用维持剂量的胺碘酮,可导致甲状腺功能失调,引起甲状腺功能减退或亢进。因为胺碘酮片(200mg)含无机碘75mg,几乎超
Amiodarone has anti-adrenergic activity, can increase the heart’s energy reserves, reduce myocardial oxygen consumption; both dilation of coronary arteries, anti-α- and β-adrenergic receptors and anti-arrhythmic pharmacological properties in the clinical widely For the treatment and prevention of ventricular and supraventricular arrhythmias. However, amiodarone can cause the temporary reduction of thyroid hormone synthesis and secretion, inhibit T_4 in the peripheral tissue into T_3 process, and improve the resistance of peripheral target cells to thyroid hormone. Long-term use of maintenance dose of amiodarone, can lead to thyroid dysfunction, causing hypothyroidism or hyperthyroidism. Because amiodarone tablets (200mg) containing inorganic iodine 75mg, almost super