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目的:了解江苏部分地区人群中谷胱甘肽转硫酶GSTM_1和GSTT_1基因多态性与大肠癌易患性的关系.方法:应用多重PCR法.对照研究55例大肠癌患者和62例健康人的GSTM_1和GSTT_1基因频率.结果:在健康对照和大肠癌病例中,GSTM_1基因缺失频率分别为53.2％和61.8％,GSTT_1基因缺失频率分别为50.0％和56.4％,病例组基因缺失频率高于健康对照组,但无显著性差异(P＞0.05).结论:GSTM_1和GSTT_1基因缺失与大肠癌易患性和发病年龄无明显相关性.“,”Objective: Investigating the relationship between polymorphism of GSTM1 and GSTT1 gene and genetic susceptibility to colorectal cancer (CRC). Methods: Genomic DNA of 55 cases with CRC and 62 healthy controls have been used to analysis the genotypes and genetic polymorphism of the GSTM1 and GSTT1 genes by multi-PCR. Results: In healthy control group and CRC patient group, the percentages of GSTM1 null type were 53.2% and 61. 8% respectively, whereas those of GSTT1 were 50.0% and 56.4%. Compared with the healthy control group, the percentage of null types in the patient group was higher, but no significant difference was found. Conclusions: The polymorphism of the GSTM1 and GSTT1 genes may be not related with genetic susceptibility to CRC and to the age of onset at CRC.