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目的：研究尼莫地平（Ｎｉｍ）对大鼠体内血小板聚集和动脉血栓形成的影响．方法：比浊法测定血小板的聚集率和抑制率；电刺激法测定Ｎｉｍ对体内动脉血栓形成的影响，放免法测定Ｎｉｍ对血浆６酮前列腺素Ｆ１α和血栓素Ｂ２（６ｋｅｔｏＰＧＦ１α／ＴＸＢ２）含量的影响．结果：Ｎｉｍ４５，９，１８和３６ｍｇ·ｋｇ－１·ｄ－１ｉｇ４ｄ可显著抑制血小板的聚集．ＩＣ５０（９５％可信限）为２６（９－４４）ｍｇ·ｋｇ－１．Ｎｉｍ４５，９，１８ｍｇ·ｋｇ－１·ｄ－１ｉｇ４ｄ可显著延长电刺激诱导的颈动脉血栓形成时间．Ｎｉｍ９和１８ｍｇ·ｋｇ－１可明显改善血浆中６ｋｅｔｏＰＧＦ１α／ＴＸＢ２的比值．结论：Ｎｉｍ抗血栓作用部分与改善６ｋｅｔｏＰＧＦ１α／ＴＸＢ２比值有关．
AIM: To investigate the effect of nimodipine on platelet aggregation and arterial thrombosis in rats. Methods: Turbidimetric method was used to measure the platelet aggregation rate and inhibition rate. The effect of Nim on arterial thrombosis in vivo was determined by electrical stimulation method. The effect of Nim on plasma 6ketoprostaglandin F1α and thromboxane B2 (6ketoPGF1α / TXB2) content of the impact. Results: Nim4 5, 9, 18 and 36 mg · kg-1 · d-1ig4d significantly inhibited platelet aggregation. IC50 (95% confidence limit) was 26 (9-44) mg · kg -1. Nim4 5,9,18 mg · kg-1 · d-1ig4d can significantly prolong the electrical stimulation-induced carotid artery thrombosis. Nim9 and 18mg · kg-1 can significantly improve the plasma 6 keto PGF1α / TXB2 ratio. Conclusion: The anti-thrombotic effect of Nim is partly related to the improvement of 6-keto-PGF1α / TXB2 ratio.