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目的通过对比多表皮生长因子样蛋白基因10(MEGF10)不同基因型产妇产后盆底恢复,探讨此基因多态性对产后盆底恢复的影响。方法收集448例产妇的血液样本并监测其产后恢复情况,采用焦磷酸测序法对MEGF10基因多态性位点rs17164935进行分型,比较不同基因型对产妇的盆底恢复的影响。结果在纳入的448例产妇中,MEGF10基因多态性位点rs17164935 GG、GA和AA三种基因型频率分别为382、55和11,备基因型间盆底肌力评分、15s收缩次数、最大用力收缩持续时间、肌电位及肌力无统计学差异。结论MEGF10基因多态性位点rs17164935可能不影响产妇产后盆底的恢复,可能不能为分娩方式的选择提供指导。
OBJECTIVE: To compare the postpartum pelvic floor recovery among different genotypes of multiple epidermal growth factor-like protein 10 (MEGF10) gene and explore the influence of this gene polymorphism on postpartum pelvic floor recovery. Methods A total of 448 maternal blood samples were collected and monitored for postpartum recovery. Pyrosequencing was used to genotype the rs17164935 MEGF10 polymorphism site to compare the effect of different genotypes on pelvic floor recovery. Results Among the 448 pregnant women, the genotype frequency of rs17164935 GG, GA and AA in MEGF10 gene was 382, 55 and 11, respectively. The pelvic floor muscle strength score, the number of contractions in 15s, Forced contraction duration, myoelectricity and muscle strength no statistical difference. Conclusion The polymorphism site rs17164935 of MEGF10 may not affect the recovery of postpartum pelvic floor and may not provide guidance for the choice of mode of delivery.