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c-erbB - 2属于受体—酪氨酸激酶类癌基因 ,属于表皮生长因子受体家族成员之一 ,是人类肿瘤中发生改变频率最高的癌基因之一。本文就c -erbB - 2的结构、分子水平调控、与肿瘤的发生、转移以及在口腔鳞状细胞癌中的过度表达同分化、预后的关系综合文献进行综述
C-erbB-2 belongs to the receptor tyrosine kinase oncogene and belongs to a member of the epidermal growth factor receptor family and is one of the most frequently changed oncogenes in human tumors. This review summarizes the literature about the relationship between the structure and molecular level of c-erbB-2, the occurrence and metastasis of tumor and the overexpression and differentiation of oral squamous cell carcinoma