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目的:观察治疗前鼻咽癌患者血清胸甘激酶1(TK-1)水平与临床特征之间的关系。方法:77例鼻咽癌初治患者(治疗组)治疗前采用酶增强化学发光技术检测TK-1浓度,选取20名健康志愿者为对照组。收集所有患者临床特征资料,并予首程根治性放疗,随访6个月,进行近期疗效评价;所有资料经SPSS 13.0软件统计包处理,进行t检验、检验和单因素方差分析(ANOVA)。结果:治疗组治疗前TK-1浓度(3.60±1.78)ρmol/L高于对照组(0.49±0.37)ρmol/L,t=-7.737,P=0.000;鼻咽癌患者临床特征中颈动脉鞘受累、颅底受侵、颅神经受累、咽后淋巴结肿大、茎突前间隙受侵及VCA-IgA与TK-1浓度有相关性,P值均<0.05;T分期、N分期、临床分期及近期疗效与治疗前TK-1浓度显著相关,P值均<0.05;而TK-1阳性率与茎突后间隙、N分期、临床分期和淋巴结转移部位有相关性,P<0.05。其他临床特征与治疗前TK-1浓度无相关性。结论:鼻咽癌患者在治疗前检测血清TK-1浓度有重要的临床意义;TK-1浓度越高,则临床分期越晚,预后相对较差。
Objective: To observe the relationship between serum thyrotropin-1 (TK-1) level and clinical features in patients with nasopharyngeal carcinoma before treatment. Methods: 77 patients with nasopharyngeal carcinoma (treatment group) before treatment with enzyme-enhanced chemiluminescence detection of TK-1 concentration, 20 healthy volunteers were selected as the control group. All patient’s clinical features were collected and the first course of radical radiotherapy was performed. The patients were followed up for 6 months for evaluation of the short-term efficacy. All data were processed by SPSS 13.0 software package for t-test, test and one-way analysis of variance (ANOVA). Results: The TK-1 concentration (3.60 ± 1.78) ρmol / L before treatment in the treatment group was significantly higher than that in the control group (0.49 ± 0.37 ρmol / L, t = -7.737, P = 0.000) Involved in the skull base invasion, cranial nerve involvement, retropharyngeal lymph nodes, invasion of the anterior styloid process and VCA-IgA and TK-1 concentrations were related, P values were <0.05; T stage, N stage, clinical stage (P <0.05). The positive rate of TK-1 was correlated with posterior pitch, N stage, clinical stage and lymph node metastasis, P <0.05. There was no correlation between other clinical features and the concentration of TK-1 before treatment. Conclusion: The detection of serum TK-1 concentration in patients with nasopharyngeal carcinoma before treatment has important clinical significance. The higher the concentration of TK-1, the later the clinical stage, the prognosis is relatively poor.