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8-甲氧基呋喃并[3′,2′∶6,7]香豆素(8-MOP,1)与长波紫外线配合,对治疗银屑病有很好的疗效,曾引起医药、生物、化学界对其光治疗机理的广泛研究。Song等认为这与1和DNA中的碱基光环合加成反应有关,但反应究竟是经由1的激发三线态还是激发单线态至今尚未确证。本文报道1与环已烯(2)和庚烯-1(3)的光环合加成反应,并鉴定了它们的加成产物,发现加成发生在1的3,4位双键上。通过猝灭实验和动力学测定,表明反应是经由激发
8-methoxy furo [3 ’, 2’: 6,7] coumarin (8-MOP, 1) with long-wave UV, has a good effect on the treatment of psoriasis, has caused the pharmaceutical, biological, Extensive research on the mechanism of phototherapy in chemistry. Song et al. [1] consider this to be related to the photochromic addition reaction with 1 and DNA, but whether the reaction has been confirmed via an excited triplet or an excited singlet at 1 has not yet been confirmed. This paper reports the photocyclisaddition of 1 with cyclohexene (2) and heptene-1 (3), and their addition products were identified. It was found that the addition occurred at the 1, 3 and 4 double bonds. Through quenching experiments and kinetic measurements, the reaction is via excitation