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作者对四氯化碳亚慢性中毒大鼠血清GOT同工酶变化进行了动态定性测定,并与中毒大鼠肝脏病理改变进行了对比,发现m-GOT检出率随染毒累积剂量的增加而升高,出现越早的动物其肝脏病变越严重;停止染毒后病变恢复,m-GOT消失。提示该指标可以反映肝脏实质损害的程度,并且可对肝脏病变的预后进行定性的估测。本实验还发现用醋酸纤维薄膜电泳法检出血清m-GOT时,GOT总活性的临界水平约为194单位。建议将该指标作为职业性中毒肝病的批量筛选和预后判断指标。
The author of dynamic carbon tetrachloride sub-chronic poisoning rat serum GOT isoenzymes were qualitatively and qualitatively measured and compared with the pathological changes of liver poisoning rats and found that the detection rate of m-GOT with the cumulative dose increased Rise, the sooner the animals appear the more serious the liver disease; lesions stopped after exposure to recovery, m-GOT disappeared. It is suggested that this index can reflect the degree of liver damage and can make a qualitative assessment of the prognosis of liver lesion. The experiment also found that when the serum m-GOT was detected by the cellulose acetate membrane electrophoresis, the critical level of total GOT activity was about 194 units. It is suggested that this index should be taken as a batch screening and prognostic indicator of occupationally poisoned liver disease.