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人白血病细胞内环核苷酸含量异常的报道较多,但有关白血病患者细胞外水平的研究资料至今还不多,而且对已治与未治病人未作明显区别。作者测定了35名正常人、50例白血病和24例非肿瘤性疾病患者(缺铁性贫血、消化道溃疡各7例,胆石症10例)血浆及尿中cAMP和cGMP的水平。 50例白血病中急粒和急淋各15例,慢粒13例,慢淋7例。除5例慢粒急变患者以前经过治疗外,余均为新近诊断未治患者。其中21例急白患者化疗期间定期测定了血浆环核苷酸水平,16例(急淋9例,急粒7例)患者于完全缓解后进行了复查。全部患者的血清肌酐和血钙均正常。
Human leukemia cells endocyclic nucleotide abnormalities are reported more, but extracellular levels of leukemia in patients with research data so far not much, and has no difference between treated and not treated patients. The authors measured levels of cAMP and cGMP in plasma and urine in 35 normal subjects, 50 leukemia patients and 24 non-neoplastic disease patients (iron deficiency anemia, peptic ulcer in 7 and cholelithiasis in 10). Fifty cases of acute and acute leukemia in 15 cases of acute leukoplakia in 13 cases, 7 cases of chronic leaching. In addition to five cases of chronic granulomatous patients previously treated, Yu are newly diagnosed patients. Serum cyclic nucleotide levels were measured periodically in 21 patients with acute leukemia, and 16 patients (9 acute ones and 7 acute ones) underwent complete remission. All patients had normal serum creatinine and serum calcium.