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综合评价HLA-DP基因多态性与中国人群慢性乙型肝炎病毒感染和肝细胞癌的相关性。系统检索PubMed、FMJS、CNKI及万方数据库有关HLA-DP基因多态性与慢性乙型肝炎病毒感染和肝细胞癌相关性的病例对照研究,按纳入标准选择文献并提取相关信息,应用Stata 12.0软件进行Meta分析。本研究共纳入HLA-DP基因多态性与HBV易感性相关文献10篇,其中与肝细胞癌相关文献3篇。Meta分析结果显示,rs3077A、rs9277535A在显性模型下不仅与HBV感染负相关(rs3077:OR=0.57,95%CI:0.53~0.63;rs9277535:OR=0.56,95%CI:0.51~0.61),还可促进HBV感染后清除(rs3077:OR=0.60,95%CI:0.52~0.68;rs9277535:OR=0.59,95%CI:0.54~0.64),其中rs3077A在显性模型下还可降低患肝细胞癌的风险(OR=0.83,95%CI:0.74~0.93)。
Comprehensive evaluation of HLA-DP gene polymorphism and Chinese population of chronic hepatitis B virus infection and hepatocellular carcinoma correlation. PubMed, FMJS, CNKI and Wanfang database were searched for case-control studies on the association of HLA-DP gene polymorphism with chronic hepatitis B virus infection and hepatocellular carcinoma. According to the inclusion criteria, the literature was selected and the relevant information was extracted. Stata 12.0 Meta-analysis software. In this study, we included 10 articles about HLA-DP gene polymorphism and HBV susceptibility, including 3 articles related to hepatocellular carcinoma. Meta-analysis showed that rs3077A and rs9277535A were negatively correlated with HBV infection in dominant model (rs3077: OR = 0.57, 95% CI: 0.53-0.63; rs9277535: OR = 0.56, 95% CI: 0.51-0.61) (Rs3077: OR = 0.60, 95% CI: 0.52-0.68; rs9277535: OR = 0.59, 95% CI: 0.54-0.64). Among them, rs3077A could also reduce the risk of hepatocellular carcinoma (OR = 0.83, 95% CI: 0.74-0.93).