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目的探讨带状疱疹后神经痛采用加巴喷丁治疗的疗效及药理。方法选取2010年10月至2013年10月济源市疾病预防控制中心收治的90例带状疱疹后神经痛患者为研究对象,将其随机分为对照组和治疗组,每组45例,对照组在常规治疗的基础上给予布洛芬胶囊治疗,治疗组在常规治疗的基础上给予加巴喷丁治疗,对比两组患者的临床疗效。结果两组患者临床治愈率比较差异无统计学意义(P>0.05),不良反应发生率比较差异无统计学意义(P>0.05);治疗组治疗后视觉模拟评分明显低于对照组,两组比较差异有统计学意义(P<0.05)。结论加巴喷丁治疗带状疱疹后神经痛效果确切,不良反应较少,临床意义重大,值得临床推广应用。
Objective To investigate the curative effect and pharmacology of gabapentin in post-herpetic neuralgia. Methods Ninety patients with postherpetic neuralgia who were treated in Jiyuan Municipal Center for Disease Control and Prevention from October 2010 to October 2013 were selected as study subjects and randomly divided into control group and treatment group with 45 cases in each group and control group Ibuprofen capsules were given on the basis of routine treatment. The treatment group was treated with gabapentin on the basis of routine treatment, and the clinical efficacy was compared between the two groups. Results There was no significant difference in the clinical cure rate between the two groups (P> 0.05), but there was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). The visual analogue score of the treatment group was significantly lower than that of the control group The difference was statistically significant (P <0.05). Conclusion Gabapentin is effective in post-herpetic neuralgia, with less adverse reactions and clinical significance, which is worthy of clinical application.