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最近研制出的新的质子泵拮抗剂Lansoprazole,对胃酸分泌有强力而持久的抑制作用,有用性已得到承认。但是,已知H~+、K~+-ATP酶在壁细胞以外的甲状腺等处也存在。另据报告,有咪唑环的某些药物对肾上腺皮质类固醇的合成也有抑制作用。作者对49例胃溃疡和35例十二指肠溃疡患者给予Lansoprazole,探讨其疗效和对内分泌机能的影响。结果4周和8周的内镜治愈率,胃溃疡分别为54％和89％,十二指肠溃疡分别为85％和100％。症状和体征消失
Recently developed a new proton pump antagonist Lansoprazole, gastric acid secretion has a strong and lasting inhibition, usefulness has been recognized. However, it is known that H ~ + and K ~ + -ATPases are also present in the thyroid other than parietal cells. It is also reported that certain drugs with imidazole ring also inhibit the synthesis of adrenal corticosteroids. The authors administered 49 patients with gastric ulcer and 35 patients with duodenal ulcer Lansoprazole, to explore its efficacy and endocrine function. Results The endoscopic cure rates at 4 and 8 weeks were 54% and 89% for gastric ulcer and 85% and 100% for duodenal ulcer, respectively. Symptoms and signs disappear