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氨基甙类抗生素能引起螺旋器严重萎缩但血管纹不受损害,而实验表明多次用利尿酸(EA)可引起血管纹损害却不引起螺旋器改变。选50只灰鼠分成六组进行实验研究。其中第一、二、三、六组均经静脉给EA30mg/kg。第一组10只,于给药后2(3只)、6(3只)、24(4只)小时处死;第二组12只,每6小时给药一次,共2～3次,其中2只于末次给药后24小时处死;2只于48小时处死;8只于1周后处死;第三组15只,每24小时给药一次达14日,于末
Aminoglycosides can cause severe atrophy of the splices but no impairment of the blood vessel pattern. Experiments have shown that repeated use of diuretic acid (EA) causes damage to the blood vessels but does not cause spiral changes. Choose 50 squirrels divided into six groups for experimental study. The first, second, third and sixth groups were given EA30mg / kg by intravenous injection. The first group of 10 rats were sacrificed after 2 (3), 6 (3) and 24 (4) hours after the administration; the second group of 12 rats was administered every 6 hours for 2 to 3 times 2 were sacrificed 24 hours after the last dose; 2 were sacrificed at 48 hours; 8 were sacrificed at 1 week; 15 in the third group were given once every 24 hours for 14 days;