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目的 :通过抗菌活性测定来探讨磺胺醌亚胺化合物的抗菌效力及其结构与活性间的关系 ,为新的抗菌药物研制提供依据。方法 :利用二倍稀释法测定了五种磺胺醌亚胺化合物对Staphylococcusaureus、Bacillussubtilis的最低抑菌浓度。结果 :磺胺醌亚胺类化合物具有很强的抑菌活性 ,大多较母体磺胺化合物强 ,其中磺胺醌亚胺对S .aureus和B .subtilis的抑菌活性分别为氨基苯磺胺的 2 .5和 1.2倍 ,磺胺嘧啶醌亚胺的抑菌活性分别为其母体化合物的 13.1和 6 .1倍 ,磺胺噻唑醌亚胺的抑菌活性为其母体化合物的 1.0 5和 6 5 .8倍 ,而磺胺吡啶醌亚胺对B .subtilis的抑菌活性有较大程度降低 ,仅为母体化合物的 6 .7%。结论 :磺胺醌亚胺化合物有比磺胺类药物更强的抗菌活性 ,或者有与其母体化合物不同的抗菌谱
OBJECTIVE: To investigate the antimicrobial efficacy of sulfamethimide compounds and their relationship between structure and activity by antibacterial activity assay, and to provide basis for the development of new antibacterial drugs. Methods: The minimum inhibitory concentrations (RSDs) of five sulfonamidoimine compounds against Staphylococcus aureus and Bacillussubtilis were determined by double dilution method. Results: SULAMIDIN compounds showed strong antibacterial activity, mostly than the parent sulfonamide compounds. The antibacterial activity of sulfamethimone to S.aureus and B.subtilis were2.5 1.2 times, the antimicrobial activity of sulfadiazine-quinone imine were 13.1 and 6.1 times that of the parent compound respectively, and the antibacterial activity of sulfathiazomethine-quinoneimine was 1.05 and 65.8 times that of the parent compound, while the sulfonamides The antibacterial activity of pyridinone imine on B. subtilis decreased to a great extent, only 6.7% of the parent compound. CONCLUSION: Sulfoquinone imine compounds have stronger antibacterial activity than sulfonamides or have different antibacterial spectrum than their parent compounds