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目的观察雷尼替丁和庆大霉素合剂口服给药后治疗化性渍疡的疗效。方法62例消化性溃疡患者随机分成两组.对照组雷尼替丁0.15g,bid,饭后服。治疗组服用雷尼替丁同时加服庆大霉素合剂10ml,ti d,雷尼替丁用法用量同对照组,6周为一疗程。结果两组近远期疗效显示:6周治疗,两组溃疡愈合率,治疗组为90.3%,时照组为83.9%,近期疗效相同但幽门螺杆茵清除率治疗组为80.6%,对照组为29.6%。治疗组明显优于对照组(P<0.01)。溃疡复发率6、12个月治疗组明显低于对照组(P<0.01),远期疗效显示治疗组明显优于对照组。结论庆大霉素与雷尼替丁合用可降低溃疡病的复发率。
Objective To observe the curative effect of ranitidine and gentamycin on oral ulcer after oral administration. Methods 62 patients with peptic ulcer were randomly divided into two groups, the control group ranitidine 0.15g, bid, after meals. The treatment group taking ranitidine plus gentamicin mixture 10ml, ti d, ranitidine dosage and control group, 6 weeks for a course of treatment. Results The short-term and long-term efficacy of the two groups showed that the healing rate of ulcer in both groups was 90.3% in the 6-week treatment group and 83.9% in the shizhi group, with 80.6% in the short-term treatment group and 80.6% in the H. pylori eradication group, 29.6%. The treatment group was significantly better than the control group (P <0.01). The recurrence rate of ulcer in 6,12 months treatment group was significantly lower than that in control group (P <0.01). The long-term efficacy showed that the treatment group was significantly better than the control group. Conclusions Gentamycin combined with ranitidine can reduce the recurrence rate of ulcer disease.