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经x-射线测定,红霉素有无定形、脱水,二水物和市售晶型四种不同的晶型.作者对24名自愿受试者(19名女,5名男)进行了血药分析,结果表明,二水物和脱水型的吸收比无定形和市售晶型的较快,较完全.其实验如下.受试者早晨先取一次血样,随之空腹口服500mg红霉素和150ml水(实验前两天起至实验期间,禁止受试者使用任何其他药物及饮酒),于服药后的0.25、0.5、1、1.5、2、3、4和6小时取血样,分别分离出血清,置-20℃贮存备用.用微生物检测技术,测出不同时间的血清中药物浓度,并以血清浓度(μg/ml)对时间(小时)作图(图1).找出各
There were four different crystal forms of erythromycin, amorphous, dehydrated, dihydrate and commercially available crystal form by x-ray.The authors tested the blood of 24 volunteers (19 women and 5 men) Drug analysis, the results show that the absorption of dihydrate and dehydration type amorphous and commercially available crystal form faster, more complete.The experiment is as follows: Subjects take a blood sample in the morning, followed by rapid oral administration of 500mg erythromycin and 150ml of water (two days before the experiment to the experimental period, the subjects are prohibited from using any other drugs and alcohol), blood samples taken 0.25, 0.5,1,1.5,2,3,4 and 6 hours after taking the drug were isolated Serum, set aside for storage at -20 ° C. The serum concentration of the drug was measured at different times using the microbiological detection technique, and the serum concentration (μg / ml) versus time (hours) was plotted (Figure 1)