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最近有报道包涵体肌炎(IBM)与免疫异常疾病有关,现作者报道1例 Sjgren 综合征合并 IBM 患者。患者女性,70岁。患进行性肌无力10年,4年前试用激素治疗数月无效。近2年已不能上楼梯及单独步行,无延髓症状。14年来有口、眼干燥,并因左腮腺“感染”作腮腺全切除。近数年手指受冷后变得苍白。体检:股四头肌及髂腰肌明显无力,其他四肢肌、面及舌肌轻度无力。双膝反射消失,左髁反射减弱。感觉正常。双眼泪液分泌试验显示双眼泪液分泌明显减少。实验室检查:血红蛋白11.3g/dl;白细胞3200/mm~3;类风湿因子1:320,抗核抗体1:2560;循环免疫复合物332.6mg/ml(正常50～150mg/ml),
Recently, it has been reported that inclusion body myositis (IBM) is associated with immunological abnormalities. One Sjögren’s syndrome was reported in our study. Patient female, 70 years old. Progressive muscle weakness 10 years, 4 years ago trial hormone therapy for several months is invalid. Nearly two years have been unable to go up the stairs and walk alone, without medullary symptoms. 14 years, mouth, dry eyes, and parotid gland due to left parotid “infection” for total resection. In recent years the fingers became pale after being cold. Physical examination: quadriceps and iliopsoas significantly weakness, other limb muscles, face and tongue muscle mild weakness. Reflex knees, left condylar reflex decreased. Feel normal. Double tear secretion test showed significantly reduced tear secretion in both eyes. Laboratory tests: hemoglobin 11.3g / dl; leukocyte 3200 / mm ~ 3; rheumatoid factor 1: 320, antinuclear antibody 1: 2560; circulating immune complex 332.6mg / ml (normal 50 ~ 150mg / ml)