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Purpose: Compare of two treatments of simple obesity (acupuncture+ diet adjustment+ aerobic exercise with diet adjustment+ aerobic exercise), in women with simple obesity without premenopausal syndrome is the main aim of this study. Method: This is a case control study in a short duration from March 2014 up to May 2014 in Khorramabad city of Iran.80 patients with obesity were examined randomly.In this study we had four groups: 2 groups with BMI 25-30 that divided to (20 patients=observation group and 20 patients=control group); and 2 groups with BMI≥ 30 that divided to (20 patients=observation group and 20 patients=control group).Observation group treated with (acupuncture+ diet adjustment+aerobic exercise) and control group treated with (diet adjustment+ aerobic exercise).After one course of treatment, body weight, BMI, body fat and WHR,measured in all groups before and after treatment. Results: (1)In this study, we had 80 patients with obesity that were without Premenopausal syndrome that divided to four groups: two groups with BMI 25-30 that divided to (20 patients=observation group and 20 patients=control group).And two groups with BMI≥ 30 that divided to (20 patients=observation group and 20 patients=control group). (2)change of WC, HC, WHR, BMI, Body fat and body weight in BMI 25-30:after treatment, this measurements of two groups were significantly decreased.(P＜ 0/05) but in (case group=acupuncture group), the changes were more. (3)change of WC, HC, WHR, BMI, body fat and body weight in BMI≥ 30: after treatment, this measurements of two groups were significantly decreased (P＜0/05)but in case group=acupuncture group), the changes were more. Conclusion: This study showed that acupuncture can depresses the appetite by activating the satiety center in the hypothalamus.So increasing beta endorphin level and serotonin at the end of treatment, causes weight loss.Because of this,effect of acupuncture combined with aerobic exercise and diet adjustment, was more obvious at the end of treatment in BMI, body weight, body fat and WHR.Also the effect of acupuncture in cases with BMI 25-30, and ≥ 30 was nearly similar.So treatment by acupuncture is one of the effective and safe methods for simple obesity.