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Orthotopic xenograft animal model from human glioblastomamultiforme (GBM) cell lines often do not recapitulate an extremely importantaspect of invasive growth and epidermal growth factor receptor (EGFR) geneoverexpression of human GBM. We developed an orthotopic xenograft modelby solid transplantation of human GBM into the brain of nude mouse. Theorthotopic xenografts sharing the same histopathological features with theiroriginal human GBMs were highly invasive, and retained the overexpression ofEGFR gene. The murine orthotopic GBM models constitute a valuable in vivosystem for preclinical studies to test novel therapies for human GBM.