Predicting Cell States and Developmental Routes from the Emerging Properties of a Core Endogenous Ne

• 作 者: 苏杭 王高伟 敖平
• 机 构: 上海交通大学系统生物医学研究院,教育部重点实验室,上海200240上海交通大学系统生物医学研究院,教育部重点实验室,上海200240;上海交通大学生物医学工程学院,上海200240;上海交通大学医学院
• 出 处: 第七届全国生物信息学与系统生物学学术大会
• 发表日期: 2016年10期
• 关键词: Early myeloid cell-fate determination Endogenous network Stable state Transition

　　Revealing the cell-fate determination and coordination during hematopoietic development is fundamental to our understanding of tissue-homeostasis,malignancy and regenerative medicine.A standard roadmap for the cell-fate diversification during hematopoiesis had been established experimentally,which highlights the stepwise and hierarchical features,yet little was known for its underpinning dynamical mechanism[1-3].In addition,many aspects of the hematopoietic development are still controversial: further experimental evidences have led to a series of suggested revisions of the standard roadmap,but a clear consensus on hematopoiesis is still missing[4,5];the "reprogramming" or "trans-programming" events have been extensively observed in experiments,which raised questions for the hierarchical model of development[6-8].