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The metastasis of malignant tumors is a complex and multistep process.[1] This might account for the failure of conventional chemotherapy,which target only part of the mechanisms underlying cancer metastasis.In this study,novel host-guest gold nanorods(GNRs)loading Docetaxel(DTX)and siRNA were developed for chemo-,RNA interference(RNAi)and photothermal ablation(PTA)combinational treatment of metastatic breast cancer.