1,4-Naphthoquinones(1,4-NQs)are a class of aromatic motifs that are widely present among natural products and synthetic analogues.Numerous 1,4-NQs derivatives with substituent at C-2 and-3 positions h
Adenosine 5-monophosphate activated protein kinase(AMPK)is a master sensor of cellular energy,which regulates the whole-body energy homeostasis.The activation of AMPK can lead to an increase of glucos
Metabotropic glutamate receptors(mGluRs)have long been considered attractive therapeutic targets for a variety of neurological and psychiatric disorders.But targeting a specific mGluR through the use
G protein-coupled receptor 119(GPR119)is a rhodopsin-like,class A Gs-coupled GPCR,which is predominately expressed in human pancreatic β-cells,where it mediates insulin secretion,and in gastrointestin
An expedient,copper-mediated,direct C-H(sp2)/C-H(sp3)bond coupling of benzoic acid derivatives with ethyl cyanoacetate by the deployment of an 8-aminoquinoline moiety as a bidentate directing group is
Baicalin is the most abundant ingredient of Scutellaria baicalensis,which has been shown to have a variety of biological activities.In this study,we have developed an efficient synthetic route for thi
Coibamide A is a highly N-methylated cyclodepsipeptides,which was isolated by McPhail and co-workers from a Panamanian marine cyanobacterium in 2007.[1] Coibamide A exhibited attractive low-nanomolar
Controlled release of peptides by plasma albumin is a successful strategy to extend half-life and improve their therapeutic effects.The short plasma half-life of thymopentin(TP5)has dramatically limit