Chemical modification,consisting of phosphorodithioate(PS2)and 2-O-Methyl(2-OMe)MePS2 on one nucleotide that significantly enhances potency and resistance to degradation for various siRNAs.
富勒烯的独特笼形结构赋予它特殊的物化性质及生物效应，有研究表明富勒烯对肿瘤细胞的生长有抑制作用，且能提高阿霉素等抗癌药物的效力，降低副作用。
Benzimidazole moiety is a structural isostere of naturally occurring nucleotides and it has been extensively utilized as a drug scaffold in the medicinal chemistry.
目的：G9a(常染色质组蛋白赖氨酸N-甲基转移酶2,euchromatic histone-lysineN-methyltransferase 2,EHMT2)的C-端含有经典的SET(Su(var),Enhancer of zeste,Trithorax)结构域,且毗邻两个富含半胱氨酸的区域,结构类似已知的组蛋白甲基转移酶Suv39h1,与Suv39h1 相比G9a 甲基催化活性高10～20 倍
Histone lysine specific demethylase 1(LSD1)is the first identified histone demethylase,which can demethylate mono-and di-methylated histon3 lysine 4(H3K41/2)and histone 3 lysine 9(H3K9me1/2)when it is
目前，胃癌在我国乃至全球范围内仍然是最常见的恶性肿瘤之一，其每年的死亡人数在各类癌症中排第二位[1]。手术、化疗和放疗是治疗胃癌的三大主要手段。
Lysine specific demethylase 1(LSD1)selectively removes methyl groups from monoand dimethylated histone 3 lysine 4(H3K4),lead to gene silencing[1].
海参硫酸软骨素(sea cucumber chondroitin sulfate)最早由Vieira 和 Mour(a)o[1]小组于1988 年从Ludwigothurea grisea 海参体壁中分离得到。
Various glycoglycerolipids isolated from natural products display notable anti-tumor,anti-viral and anti-inflammatory bioactivities.
1,4-Naphthoquinones(1,4-NQs)are a class of aromatic motifs that are widely present among natural products and synthetic analogues.Numerous 1,4-NQs derivatives with substituent at C-2 and-3 positions h