Association of mitochondrial DNA copy number in peripheral blood leukocytes with risk and prognosis

• 作 者: Weimin Zhou Kuangbiao Zhong
• 机 构: Department of Urology, the Third Xiangya Hospital of Central South University, Changsha 410013, Chin
• 出 处: GTAUF2014 & APSMHA2014第六届长城泌尿男科转化医学论坛暨第七届亚太男性健康与抗衰老研究学会年会
• 发表日期: 2014年11期
• 关键词: Prostate cancer (Pca) mitochondrial DNA (mtDNA) cancer risk prognosis

Objective: To investigate the relationship between mitochondrial DNA (mtDNA) copy number in peripheral blood leukocytes (PBLs) and the risk and the prognosis of prostate cancer (PCa).Methods: In a case-control study of 196 PCa patients and 196 age-paired normal controls, the association between mtDNA copy number in PBLs and PCa risk was evaluated.The relative mtDNA copy number was measured by using real-time PCR.Among the case cohort, 89 patients were subject to follow-up.Two endpoints i.e., progression-free survival (PFS) and overall survival (OS), were selected to evaluate the association between the prognosis of PCa and the mtDNA copy number.