【摘 要】
：
Thiopeptides,with potent activity against various drug-resistant pathogens,share a characteristic macrocyclic core that consists of a nitrogen-containing.6-
【机 构】
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StateKeyLaboratoryofBioorganicandNaturalProductsChemistry.City.Shanghai
【出 处】
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15th International Symposiium on the Biology of Actinomycete
论文部分内容阅读
Thiopeptides,with potent activity against various drug-resistant pathogens,share a characteristic macrocyclic core that consists of a nitrogen-containing.6-membered ring central to multiple thiazoles and dehydroamino acids [1].Their biosynthetic pathways remain elusive in spite of great efforts by in vivo feeding experiments Here.cloning,sequencing and characterization of the thiostrepton,siomycin A,and nosiheptide gene clusters unveiled a new biosynthetic paradigm for the thiopeptide specific core formation,featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications [2-5].
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