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The evolvement and the building breakage of a residential natural gas leakage explosion accident happened in Beijing was simulated as the study target.The simulation model of the explosion accident spot was set up by AutoReaGas,and 99 measurement points were distributed at the comers of room in the model.The evolvement and building breakage of explosion accident under 8 kinds of boundary (CASE1-CASE8) were analyzed.The changes over time of overpressure at each measurement points and the building breakage when the accident occurred were gained,and the simulation results show that the building breakage caused by the natural gas explosion in CASE1 and CASE5 are the most similar conditions to the accident spot,and the pure natural gas leakage capacity of the explosion accident is between 6.48 m3-19.65 m3.