Part 3 Clinical Effects Analysis on Combination of Accelerator Linear and Gamma Knife Radiotherapy w

• 出 处: The 15th Asia-Oceania Congress of Medical Physics (AOCMP2015
• 发表日期: 2015年7期
• 关键词: Accelerator Linear Gamma Knife DP Concurrent Radiotherapy and Chemotherapy Local

　　Objective:To observe the short-term effects and adverse reactions of combination of acceleratorlinear and gamma knife radiotherapy with concurrent DP chemotherapy for locally advanced non-small celllung cancer(NSCLC).Methods:Ninety-six patients with locally advanced NSCLC were randomly assigned to three treatmentarms.In group A,patients were received accelerator linear and gamma knife radiotherapy with concurrent 4cycles of DP chemotherapy.The total dose was 50Gy/25F by accelerator linear using 6MV x-rays.Thepatients were then received gamma knife radiotherapy with the total dose of 20Gy/4F,once every other day.In group B,patients were received accelerator linear radiotherapy with concurrent 4 cycles of DPchemotherapy.The total dose was 60~66Gy/30~33F.In group C,patients were received acceleratorlinear radiotherapy using 6MV x-rays with the total dose of 60~66Gy/30~33F after 2 cycles of DPchemotherapy,and then received another 2 cycles of DP chemotherapy.Results:Ninety patients finished the treatment.The overall response rate of the three groups was 87.1%,86.7%and 62.1%,respectively(PAB=1.000,PAC=0.025,PBC=0.030).The overall 1-year survival rate of thethree groups was 77.4%,73.3%and 72.4%,respectively(PAB=0.711,PAC=0.655,PBC=0.937).The adversereactions were radiation pneumonitis,radiation esophagitis,gastrointestinal effects and myelosuppression.The incidence rates of radiation pneumonitis higher than firstgrade were 32.3%,60.0%and 20.7%,respectively(PAB=0.030,PAC=0.311,PBC=0.002).The incidencerates of myelosuppression higher than first grade were 61.3%,66.7%and31.0%,respectively(PAB=0.662,PAC=0.019,PBC=0.006).Conclusion:The combination of accelerator linear and gamma knife radiotherapy with concurrent DPchemotherapy can improve the short-term effects in locally advanced NSCLC patients with acceptabletoxicity.But the long-term effects and toxicity should be further researched.