论文部分内容阅读
本课题组前期从五谷虫[1,2]的70％的甲醇提取液中提取得到了微量的活性氟化合物苯甘氨酸氟甲酯(1)。初步药理筛选结果显示化合物1具有较强的抗枯草杆菌活性,较青霉素作用更加显著 [3]。
含氟抗菌剂苯甘氨酸氟甲酯的合成
【摘 要】
：
本课题组前期从五谷虫[1,2]的70％的甲醇提取液中提取得到了微量的活性氟化合物苯甘氨酸氟甲酯(1)。初步药理筛选结果显示化合物1具有较强的抗枯草杆菌活性,较青霉素作用更加显著 [3]。
【机 构】
：
河南科技大学化工与制药学院;河南省伏牛山野生药材基源工程技术中心,洛阳,471023 河南科技大学
【出 处】
：
河南省化学会2016年学术年会
【发表日期】
：
2016年10期
其他文献
In the synthesis of 2-(4-fluorophenyl)thiophene(1),the 1-bromo-4-fluorobenzene and 2-bromothiophene was used as starting material,the highest yield was obtained when reaction time was 8h at 20℃ ; 2 an
The study on Organic Electroluminescence Devices(OELDs)have become one of the fascinating fields recently.Compared with Inorganic Electroluminescence Devices,OELDs possess excellent features,such as h
As one of alkaloids,matrine have widely biological activities,especially good anti-tumor effect and better mechanism of action than others.But because of its four-chain structure and poorly water-solu
In the synthesis of N-Boc-5-methyl-1H-pyrrol-2-ylboronic acid(4),the pyrrole was used as starting material,through Vilsmere reaction,LiAlH4 reduction,protection of BOC anhydride,treatment with n-butyl
Synthesis and development of fluorescent molecules is a thriving area,which has been put into application in advanced materials configuration and device fabrication.Among various fluorescent molecular
The 1,2,3-triazole scaffold plays an important role in medicinal arena as numerous molecules bearing this framework are endowed with HIV protease inhibiting,anticancer,antituberculosis,antifungal,or a
Imidazopyridine compounds are important nitrogen-containing heterocycles existing widely in natural products,pharmaceuticals,pesticides,and dyes.In another aspect,chromenone derivatives are found to b
The 2,2-biphenol framework is frequently found in natural products,pharmaceuticals and functional materials.Moreover,2,2-biphenol and its derivatives are also acting as efficient ligands in numerous m
Many chiral acyclic nucleoside analogues exhibit outstanding anti-virus and anti-cancer activities.Thus,developing efficient synthesis methods to construct chiral acyclic nucleoside analogues have att
1,3-氧氮天然生物碱Chinese Bittersweet Alkaloid(1)和(2)是一类具有全新骨架的生物活性化合物[1]。作为生物活性的研究,经过美国NCI癌症研究中心筛选,该类化合物中化合物(2)在筛选的9个细胞系的60个癌细胞株中对非小细胞肺癌HOP-92细胞株展现出良好的抑制活性。
会议