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  5. A virtual screening approach for Cdk5/p35 inhibitors based on common feature pharmacophore modeling

A virtual screening approach for Cdk5/p35 inhibitors based on common feature pharmacophore modeling

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：z344121483
【摘 要】
：
Aim: Cdk5 is an a typical cyclin-dependent kinase localized in the brain, and its activity is dependent upon binding to p35.Cdk5/p35 plays an important role in the hyperphosphorylation of tau protein,
【作 者】
：
Ran-yao YANG Jian-song FANG Ai-lin LIU Guan-hua DU 
【机 构】
：
Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Bei
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
CdkS/p35 inhibitors virtual screening pharmacophore molecular docking Alzheimer& 
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Aim: Cdk5 is an a typical cyclin-dependent kinase localized in the brain, and its activity is dependent upon binding to p35.Cdk5/p35 plays an important role in the hyperphosphorylation of tau protein, which has been observed in Alzheimers Disease (AD) patients.CdkS/p35 represents an attractive drug target in AD.In this study, we aim to find the inhibitors of cdk5/p35 using virtual screening technology.
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