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HAMPT is a quardruple combination drug consisted of mifepristone,aspirin,lysine and doxycycline.It was specifically designed for synergistically controlling key cancer metastatic pathways.The dose of HAMPT was designed at lower than the pharmaceutically-recommended dose,and thus the sub-healthy cancer survivors may take HAMPT safely and long for metastasis chemoprevention.Based on our previous study,here,we further proved that HAMPT could effectively and safely prevent colon cancer metastasis.