Anti-Tumor Immune Response of Folate-Conjugated Chitosan Nanoparticles Containing the IP-10 Gene in

• 作 者: ChunhuiLai[1]SufangZhou[1]YongxiangZhao[1]XiaolingLu[2]XiaYu[1]HuiqinZhuo[3]NuoZhou[4]YuanXie[1]JianHe[1]YiPeng[1]XiaoxunXie[1]GuorongLuo[1]
• 机 构: National Center for International Research of Biological Targeting Diagnosis and Therapy,Guangxi Med
• 出 处: 中国病理生理学会第十四届肿瘤专业委员会、第十五届免疫专业委员会联合学术会议
• 发表日期: 2014年期

　　Immunotherapy is one of the most promising new therapies for hepatocellular carcinoma (HCC) in recent years.In this study,folate-conjugated chitosan nanoparticles (FA-CS-NPs) were loaded with mouse interferon-y-inducible protein-10 (IP-10) plasmid,which were used for immunotherapy in HCC.H22 tumor-bearing mice were treated with FA-CS-NPs entrapped IP-10 plasmid and targeting efficiency was observed by optical imaging in vivo.Flow cytometry was used to measure the number of myeloid-derived suppressor cells (MDSCs) in the tumor and CD4+CD25+FoxP3+ T-regulatory ceils (CD4+CD25+FoxP3+ Tregs) in the spleen.