CD5+CD1d hi小鼠调节性B细胞(Breg)与其它B细胞亚群相比增殖减弱凋亡增加

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：wdqbupt

【摘要】

：

【作者】

：

王铿曾祥周陶磊张悦阳李晓娟

【机构】

：

南方医科大学药学院

【出处】

：

中国免疫学会第九届全国免疫学学术大会

【发表日期】

：

2014年8期

【关键词】

：

调节性B细胞(Breg) 增殖凋亡 FasL

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

调节性B细胞(Breg)是体内发挥负向免疫调节功能的一群重要免疫细胞,其功能主要部分地通过分泌IL-10来实现,而CD5+CD1d hi B细胞是目前报导最多的一群小鼠Breg细胞.LPS是激活小鼠Breg细胞分泌IL-10的有效因子.本研究分离小鼠脾脏淋巴细胞,用LPS激活Breg,培养24-72小时.CFSE染色结果表明,LPS刺激48-72h后,CD19+CD5+CD1d hi Breg细胞亚群比CD19+CD5+CD1dlow和CD 19+CD5negB细胞亚群增殖明显减弱;而刺激24-48小时后CD19+CD5+CD1d hi Breg细胞群Annex-Ⅴ表达比其余两个B细胞亚群显著升高,其中CD19+CD5neggB细胞亚群表达最低;与此同时CD 19+CD5+CD1d hi Breg亚群FasL表达高于其它B细胞亚群,与Annex-Ⅴ表现一致.

其他文献

The expression of vesicular glutamate transporter 3 and vesicular monoamine transporter 2 induced by

The vesicular glutamate transporter 3 (VGLUT3) and the vesicular monoamine transporter 2 (VMAT2) are expressed in dorsal root ganglion (DRG) neurons and play an important role in packing the neurotran

会议

The effects of galanin on neuropathic pain in streptozotocin-induced diabetic rats

Diabetic neuropathy is a common complication associated with diabetes and is frequently painful.However,mechanisms responsible for diabetic neuropathic pain are still unclear.Experimental evidence has

会议

Insulin-like growth factor-1 attenuates apoptosis and protects neurochemical phenotypes of dorsal ro

Paclitaxel (PT)-induced neurotoxicity is a significant problem associated with successful treatment of cancers.Insulin-like growth factor-1 (IGF-1) has neurotrophic effects on dorsal root ganglion (DR

会议

Effect of Lipoic acid on the release cytokines and chemokines in cultured astrocytes stimulated by l

To investigate the effect of Lipoic acid on the release of cytokines (TNF-α, IL-1 β, IL-6 and IL-10) and the expression of chemokines (CCL2, CCL3, CCL5 and CCL20 mRNA) in cultured astrocytes stimulate

会议

Basal nuclei or Basal ganglia? A Serious incongruity by the non recognition of terminology in neuroa

To argue about the inconsistency of the correct use of the neuroanatomical terminology to name basal nuclei in the neurological field.Papers published in PubMed during the month of July of 2013 were t

会议

Network of excellence in education-simulation of medical procedures on cadavers

The mastery of minimally invasive techniques becomes one of the basic needs for completion in different medical specializations.Practical training shifts from demonstrations limited to an operating th

会议

Adaptive tutorials in radiologicai anatomy

During the first two years of the medical program at The University of Queensland, ten 2-hour radiological anatomy tutorials have been introduced to supplement the existing gross anatomy practical ses

会议

Evolving anatomy education: The impact on osteopathic programs

Anatomy has been the cornerstone subject in the education of health professionals.One of the professions in which anatomy plays a prominent role is osteopathy.Anatomical knowledge is essential for the

会议

对调控者的调控:泛素化系统的自身调控及机制

泛素化修饰是最早被发现的蛋白翻译后修饰,是在底物蛋白上加上泛素分子的酶促过程.由泛素活化酶、泛素结合酶与泛素连接酶催化完成.该过程在细胞周期的调控、DNA损伤与修复、细胞生长与凋亡、免疫应答与炎症反应、抗原提呈等多种生物过程中发挥重要作用,对该过程的精确调控具有十分重要的意义.泛素化过程可以在多个层次进行调控,然而近年来的研究表明,决定泛素化特异性的成分——E3连接酶及其它一些成分同样可以被泛素化

会议

Therapeutic effects of exosomes derived from atorvastatin-modified bone marrow dendritic cells on ex

Background: We have demonstrated previously that spleen-derived dendritic cells (DCs) modified with atorvastatin can suppress immune response in experimental autoimmune myasthenia gravis (EAMG).The th

会议

AtorvastatinExosomesExperimental autoimmune myasthenia gravisIDOFasL

CD5+CD1d hi小鼠调节性B细胞(Breg)与其它B细胞亚群相比增殖减弱凋亡增加

其他学术论文