Therapeutic effects of exosomes derived from atorvastatin-modified bone marrow dendritic cells on ex

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：uilyz

【摘要】

：

【作者】

：

Xiao-Li Li Heng Li Min Zhang Hua Xu Long-Tao Yue Xin-Xin Zhang Shan Wang Cong-Cong Wang Yan-Bin Li Ying-Chun Dou Rui-Sheng Duan

【机构】

：

Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, 250014

【出处】

：

中国免疫学会第九届全国免疫学学术大会

【发表日期】

：

2014年8期

【关键词】

：

Atorvastatin Exosomes Experimental autoimmune myasthenia gravis IDO FasL

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

Background: We have demonstrated previously that spleen-derived dendritic cells (DCs) modified with atorvastatin can suppress immune response in experimental autoimmune myasthenia gravis (EAMG).The therapeutic effects are mediated by exogenous DCs that can migrate to immune organs and decrease the expression of CD86 and MHC class Ⅱ on endogenous DCs, which could further induce T cell anergy and immune tolerance in EAMG rats.Increasing evidences from animal experiments and clinical studies have shown that exosomes (EXOs) have involved in the immune regulation.In particular, EXOs derived from DCs can carry regulatory molecules and target to their corresponding acceptor cells.

其他文献

Effects of neuregulin-1β on growth-associated protein 43 expression in dorsal root ganglion neurons

Neuregulin-lβ (NRG-1β) is a growth factor with potent neuroprotective capacity.Growth-associated protein 43 (GAP-43) is expressed in dorsal root ganglion (DRG)neurons and an indicator of neuronal surv

会议

The expression of vesicular glutamate transporter 3 and vesicular monoamine transporter 2 induced by

The vesicular glutamate transporter 3 (VGLUT3) and the vesicular monoamine transporter 2 (VMAT2) are expressed in dorsal root ganglion (DRG) neurons and play an important role in packing the neurotran

会议

The effects of galanin on neuropathic pain in streptozotocin-induced diabetic rats

Diabetic neuropathy is a common complication associated with diabetes and is frequently painful.However,mechanisms responsible for diabetic neuropathic pain are still unclear.Experimental evidence has

会议

Insulin-like growth factor-1 attenuates apoptosis and protects neurochemical phenotypes of dorsal ro

Paclitaxel (PT)-induced neurotoxicity is a significant problem associated with successful treatment of cancers.Insulin-like growth factor-1 (IGF-1) has neurotrophic effects on dorsal root ganglion (DR

会议

Effect of Lipoic acid on the release cytokines and chemokines in cultured astrocytes stimulated by l

To investigate the effect of Lipoic acid on the release of cytokines (TNF-α, IL-1 β, IL-6 and IL-10) and the expression of chemokines (CCL2, CCL3, CCL5 and CCL20 mRNA) in cultured astrocytes stimulate

会议

Basal nuclei or Basal ganglia? A Serious incongruity by the non recognition of terminology in neuroa

To argue about the inconsistency of the correct use of the neuroanatomical terminology to name basal nuclei in the neurological field.Papers published in PubMed during the month of July of 2013 were t

会议

Network of excellence in education-simulation of medical procedures on cadavers

The mastery of minimally invasive techniques becomes one of the basic needs for completion in different medical specializations.Practical training shifts from demonstrations limited to an operating th

会议

Adaptive tutorials in radiologicai anatomy

During the first two years of the medical program at The University of Queensland, ten 2-hour radiological anatomy tutorials have been introduced to supplement the existing gross anatomy practical ses

会议

Evolving anatomy education: The impact on osteopathic programs

Anatomy has been the cornerstone subject in the education of health professionals.One of the professions in which anatomy plays a prominent role is osteopathy.Anatomical knowledge is essential for the

会议

对调控者的调控:泛素化系统的自身调控及机制

泛素化修饰是最早被发现的蛋白翻译后修饰,是在底物蛋白上加上泛素分子的酶促过程.由泛素活化酶、泛素结合酶与泛素连接酶催化完成.该过程在细胞周期的调控、DNA损伤与修复、细胞生长与凋亡、免疫应答与炎症反应、抗原提呈等多种生物过程中发挥重要作用,对该过程的精确调控具有十分重要的意义.泛素化过程可以在多个层次进行调控,然而近年来的研究表明,决定泛素化特异性的成分——E3连接酶及其它一些成分同样可以被泛素化

会议

Therapeutic effects of exosomes derived from atorvastatin-modified bone marrow dendritic cells on ex

其他学术论文