【摘 要】
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Tetracyclic tetrahydroprotoberberines (THPB) alkaloids contain an isoquinoline backbone and was endowed with various biological properties such as analgesic,anti-convulsant,anti-depressant and anti-ps
【机 构】
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Laboratory of Bioorganic & Medicinal Chemistry, School of Chemistry and Chemical Engineering, Southw
【出 处】
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中国化学会第十三届全国有机合成化学学术研讨会
论文部分内容阅读
Tetracyclic tetrahydroprotoberberines (THPB) alkaloids contain an isoquinoline backbone and was endowed with various biological properties such as analgesic,anti-convulsant,anti-depressant and anti-psychotic abilities in the central nervous system.Despite the rapid progress of science,the treatment of infectious diseases still remains a serious problem to the scientific community.A key intermediate containing an aldehyde group at 12-position of tetrahydroprotoberberrubine was developed for future modification.This aldehyde is easy to be attacked by neucleophilic reagents to access a series of berberrubine modified benzimidazole derivatives that can ameliorate the weakness of berberine.
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