论文部分内容阅读
Currently surgery provides the best chance of cure for colorectal carcinoma (CRC).Unfortunately, effective treatment is frequently complicated by peritoneal recurrences and development of distant metastases, even after intentional curative resection of the primary tumor.We previously demonstrated that surgical trauma promotes outgrowth of peritoneal as well as liver metastases.Hence, removal of primary colorectal carcinoma may paradoxically increase the risk of metastases development.We showed that the inflammatory reaction of the peritoneal cavity as a result of surgery causes increased adhesion of rat CC53 1s colon carcinoma cells to both submesothelial extracellular matrix (ECM) proteins of the peritoneum and to subendothelial ECM in the liver, leading to enhanced tumor development.