High-throughput functional genomics approach for reconstruction and modulization of metabolic and re

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  Thermoanaerobic bacteria are of interest in cellulosic-biofuel production due to extreme-temperature growth and simultaneous pentose and hexose utilization (coutilization).Using high-throughput functional genomics approaches, we have experimentally reconstructed the structure and dynamics of the genome-wide carbonutilization network of thermoanaerobes.The network uncovered numerous novel pathways and pinpointed previously unrecognized yet crucial pathway-interactions and the associated key junctions.
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