【摘 要】
：
The three major types of multidrug resistance (MDR) transporter proteins in humans include members of the ABCB,the ABCC,and the ABCG subfamily.These pumps r
【机 构】
：
Membrane Biology Research Group Hungarian Academy of Sciences Semmelweis University Hungary
【出 处】
：
中国上海第七届国际新药发明科技年会
论文部分内容阅读
The three major types of multidrug resistance (MDR) transporter proteins in humans include members of the ABCB,the ABCC,and the ABCG subfamily.These pumps recognize a wide range of drug substrates,mostly hydropbobic compounds,but also a variety of amphipathic anions and cations.MDR-ABC proteins play an important role in cancer drug resistance,but also in the absorption,distribution,metabolism and toxicity (ADME-tox) of several pharmaceutical agents.
其他文献
刘蓓早就是大红大紫的影视明星了。《过把瘾》中的出镜使她获得第十二届大众电视金鹰奖最佳女配角奖：《甲方乙方》的上映让她赢得第十二届大众电影百花奖最佳女主角奖等等。在
Peptides derived from the venoms of marine cone snails have attracted recent attention as potential therapeutic agents for the treatment of chronic pain.Alt
地膜西瓜后期早衰的主要表现是,长势减弱,生长缓慢,上部叶片瘦小,叶色淡绿,叶片变薄,下部叶片变黄或褐,瓜重、品质下降和大面积减产。早衰的原因１、脱肥种西瓜一般基肥施的较
在移动A d hoc网络研究中,路由协议的研究一直都是学术界广泛关注的焦点,围绕A d hoc网络的路由协议,已经开展了大量的研究工作,具有成果性的协议主要有DSR,AODV,DSDV和TORA
We are developing an alternative approach to siRNA,which may be designated as siDNA,small interfering DNA,by using hairpin-loop-structured DNA oligodeoxynuc
近年来，随着城市绿化对草坪需求的增加，培育草坪已成为一条新的致富门路，市场前景看好。在沿海一些城市，草坪的覆盖率正以每年３０％左右的速度递增。这些城市对草坪的需求旺盛，在绿化中
The demands to reduce R&D costs in of new drugs and to improve the high attrition rate of drug candidates in development have shifted to early discovery pha
小裙子预示未来 1922年7月2日,在威尼斯近郊一户贫苦农家,小卡丹出生了。两年后,第一次世界大战的战火遍及意大利。在法国东南部的格勒诺布尔,全家人勉强定居下来。老卡丹每
１ 稻草选用不佳应选用色泽金黄、干燥、无霉变的新鲜稻草。陈年稻草要剔除腐烂霉变或受污染的部分 ,并翻晒２～３天。最好选用能饲喂耕牛的稻草。２ 软化处理不当稻草表层裹有较厚的蜡
Neuroactive peptides that target ion channels or receptors are attractive sources of therapeutics for neurological diseases,but because of their peptidic na