【摘 要】
：
Microsatellite instability (MSI) has been observed within tumors and found to be closely associated with the degree of malignancy and prognosis in tumors.Ho
【机 构】
：
DepartmentofGenetics,SchoolofBasicMedicalScience,BeijingKeyLaboratoryofCancerInvasion&MetastasisRese
【出 处】
：
首都医科大学第四届研究生学术论坛第二分论坛
论文部分内容阅读
Microsatellite instability (MSI) has been observed within tumors and found to be closely associated with the degree of malignancy and prognosis in tumors.However,whether MSI in tumor-related genes can be induced by a chemical and whether a connection exists between MSI and tumors remain unclear.In the present study,we detected MSI in the tissuesof N-methyl-N-nitrosourea (MNU)treated mice by targeting to 5,29,30 microsatellite loci in 3 mismatch repair (MMR) genes,1 DNA repair gene,and 5 tumor suppressor (TS) genes,respectively.Among 26 mice survived in the MNU-group,18(69%) mice presented thymic lymphomas.
其他文献
Background: To evaluate the prognostic outcomes and risk factors for renal cell carcinoma (RCC) patients with venous tumor thrombus in China.Methods: We rev
Urothelial carcinoma of the bladder remains a significant oncologic problem throughout the world and is a source of both morbidity and mortality.Despite adv
Cannabinoid receptors (CBs) have been implicated in the pathogenesis of various liver diseases,including liver fibrosis.Our previous studies have demonstrat
Penile preserving and reconstructive surgery is applied in the management of the primary tumor in penile cancer as well as severe genital anomalies or loss.
Prostate cancer is the most commonly diagnosed non-cutaneous solid malignant tumor in the United States.Traditionally,Asian men have been considered low ris
The successful treatment of males with cancer has led to increasing numbers of men and boys interested in life after cancer.One of the top priorities for ma
Background: To report the thickness of the peripapillary retinal nerve fiber layer (pRNFL)in Chinese children and examine its association with refractive er