Super-resolution imaging and reconstructions of chromosome architecture in yeast and human cell

• 作 者: 郝先 WeberChristian OuyangWei ZimmerChristophe
• 机 构: InstitutPasteur
• 出 处: 中国化学会生物物理化学专业委员会第四届全国生物物理化学会议
• 发表日期: 2016年6期
• 关键词: super-resolution imaging chromosome architecture computational reconstruction ge

　　Chromosomes are arranged non-randomly in the 3D space of cellular nuclei.This architecture is important to key biological processes including gene expression and DNA repair,but remains poorly understood in detail.Genome-wide chromosome conformation capture(Hi-C)is currently the most powerful experimental technique to probe chromosomal structures.