【摘 要】
：
Amino acids, neurotransmitter, purines and pyrimidines are bioactive molecules playing fundamental roles in maintaining various physiological functions.Their metabolism are closely related to the heal
【机 构】
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School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, China;
【出 处】
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2015年第一届药代动力学朝阳论坛
论文部分内容阅读
Amino acids, neurotransmitter, purines and pyrimidines are bioactive molecules playing fundamental roles in maintaining various physiological functions.Their metabolism are closely related to the health, growth, development, reproduction and homeostasis of organisms.Most recently, comprehensive measurements of these metabolites have shown their potential as innovative approaches in disease surveillance or drug intervention.However, simultaneous measurement of these metabolites exists great difficulties to conquer.Here, we reported a novel quantitative method utilizing hydrophilic interaction ultra-high-performance liquid chromatography-tandem mass spectrometry (HILIC-UPLC-MS/MS) that was highly selective and high-throughput with better chromatographic behavior.
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