【摘 要】
：
Carboxylesterases (CEs), as an important class of phase Ⅰ metabolism enzymes in mammals, efficiently mediate the detoxification of environmental toxins and drug metabolism of compounds containing este
【机 构】
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Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics,Chinese Academ
【出 处】
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2015年第一届药代动力学朝阳论坛
论文部分内容阅读
Carboxylesterases (CEs), as an important class of phase Ⅰ metabolism enzymes in mammals, efficiently mediate the detoxification of environmental toxins and drug metabolism of compounds containing ester functional group.In human, most carboxylesterases that have been identified belong to two isoforms, carboxylesterase 1 (hCE1) and human carboxylesterase 2 (hCE2).hCE1 is expressed in many organs, especially in the liver, but its expression in the gastrointestinal tract is markedly low, whereas hCE2 is the major carboxylesterase isoform distributed in intestine.The selective expression of hCE2 in intestinal enterocytes may represent a defensive barrier that esterified xenobiotics need to breech before the organism is exposed following absorption.
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