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目的:探讨金钠多注射液预防静脉桥再狭窄的作用。方法:20只体重在2.5～3.0kg的新西兰兔随机分成2组,即对照组(n=10)和金钠多组(n=10),所有兔均进行颈外静脉反向吻合于颈动脉的搭桥手术,用彩超检测血流量,证明桥通畅,术后给予高脂饲料喂养。2个月后,用彩色多普勒检测静脉桥内膜厚度,并取血管桥组织标本作病理切片检查,以了解内皮细胞及平滑肌细胞有无增生迁移及血管基质有无增生等。结果:(1)术毕所有桥均通畅。(2)术后2个月彩色超声检查示金钠多组静脉桥内膜斑块形成、狭窄和内膜增厚程度均比对照组明显减轻。(3)术后2个月病理切片显示对照组的静脉桥内皮细胞脱落、内膜增生、平滑肌细胞移行增殖和脂质沉积等典型的粥样硬化变化,而金钠多组上述变化显著减轻。结论:金钠多注射液对静脉桥再狭窄有预防作用。
OBJECTIVE: To investigate the effect of JinNaoDou injection in preventing restenosis of venous bridge. METHODS: Twenty New Zealand rabbits weighing 2.5-3.0 kg were randomly divided into two groups: control group (n=10) and gold sodium group (n=10). All rabbits underwent reversed anastomosis of the external jugular vein to the carotid artery. By bypass surgery, blood flow was detected with color Doppler ultrasound to confirm that the bridge was open and postoperatively given high-fat diet. Two months later, the thickness of venous intima was measured by color Doppler, and the vascular bridge tissue specimens were taken for pathological examination to understand whether endothelial cells and smooth muscle cells had proliferated migration and vascular matrix hyperplasia. Results: (1) All bridges were open after surgery. (2) Color ultrasonography at 2 months after operation showed that the formation, stenosis, and intimal thickening of venous intimal plaques were significantly reduced in the JinNa group compared with the control group. (3) Pathological sections at 2 months after operation showed typical atherosclerotic changes such as detachment of vein endothelial cells, intimal hyperplasia, smooth muscle cell migration and proliferation, and lipid deposition in the control group, while the above changes in the Jin Nao group were significantly reduced. Conclusion: JinNaDuo injection can prevent vein restenosis.