【摘 要】
：
How the programming and reprogramming of stern/progenitor cells regulate normal cell development and cancer is still not well known.One of the tools that we
【机 构】
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Department of Cancer Genetics and Department of Neuro-Oncology The University of Texas M.D.Anderson
【出 处】
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BIT‘s2nd Annual World Cancer Congess-2009 (2009第二届癌症大会)
论文部分内容阅读
How the programming and reprogramming of stern/progenitor cells regulate normal cell development and cancer is still not well known.One of the tools that we have chosen to investigate stem cell regulation is the neuronal transcriptional repressor, RE 1-silencing transcription factor (REST).REST is expressed in most non-neural cells, including neural stem/progenitor cells (NSCs), but is absent in most neuronal ceils.Previously, we found that activation of REST target genes in NSCs, and even muscle progenitor cells, was sufficient to cause neuronal differentiation, indicating an enormous cellular flexibility of stem/progenitor cells.
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