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Microalbuminuria has been shown to be a risk factor for cardiovascular and renal disease in patients with hypertension and diabetes as well as in the general population.UACR(urinary albumin to creatinine ratio)isconsidered a sensitive indicator to detect microalbuminuria for early diagnosis of diabetic nephropathy and cardiovascular disease.Few studies have used UACR to analyze the prevalence of and related factors for microalbuminuira in a general Chinese population.A total of 6828 healthy check-up people were chosen from Huaxi Medical Center from November 2013-October 2015.Blood pressure,height,weight,Waistline and Hiplinewere measured,and a venous blood and urine samples were collected from each person.Chi-Square test and logistic regression analyses were used to test associations between risk factors and microalbuminuria.The median(25th-75th percentile)of UACR was 5.0 mg/g(2.7-11.3mg/g)for all adults,4.7mg/g(2.6-10.5mg/g)for men and 6.2mg/g(3.4-13.1mg/g)for women.The overall prevalence of microalbuminuria was 10.71%,10.52%for men and 11.28%for women.Multiple logistic regression analysis indicated that age,BMI,SBP,WHR and eGFR were independent risk factors for the development of microalbuminuria.Adults in the general population of Chinese Healthy Check-up Population have a moderate prevalence of microalbuminuria.Those with hypertension,high WHR,high GLU,high TG and elderly-age are at high risk of having microalbuminuria,suggesting the need for screening and early intervention for microalbuminuria among these individuals.