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目的：BCRP在许多肿瘤中高表达并且调节乳腺癌细胞的多药耐药性，本研究主要探讨miR-302s基因簇各成员对BCRP介导的乳腺癌耐药作用的调控及可能机制，分析各成员间的"协同效应"，为发现乳腺癌耐药形成与逆转的新切入点和基因靶点提供理论与实验依据。
miR-3021/b/c/d靶向抑制BCRP表达增加乳腺癌细胞药物敏感性及其协同效应的研究
【摘 要】
：
目的：BCRP在许多肿瘤中高表达并且调节乳腺癌细胞的多药耐药性，本研究主要探讨miR-302s基因簇各成员对BCRP介导的乳腺癌耐药作用的调控及可能机制，分析各成员间的"协同效应"，为发现乳腺癌耐药形成与逆转的新切入点和基因靶点提供理论与实验依据。
【机 构】
：
中国医科大学药学院药理教研室,辽宁沈阳 110001
【出 处】
：
中国药理学会第十三届全国化疗药理学术研讨会
【发表日期】
：
2016年4期
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