Lipid nanovehicles with adjustable surface properties for overcoming multiple barriers simultaneousl

来源 :2016年中国药物制剂大会、中国药学会药剂专业委员会2016年学术年会、中国化学制药工业协会固体制剂专业委员会2016年 | 被引量 : 0次 | 上传用户：qq616009003

【摘要】

：

【作者】

：

Lei Wu Min Liu Wei Shan Yi Cui Yuan Huang

【机构】

：

Key Laboratory of Drug Targeting and Drug Delivery System,Ministry of Education,West China School of

【出处】

：

2016年中国药物制剂大会、中国药学会药剂专业委员会2016年学术年会、中国化学制药工业协会固体制剂专业委员会2016年

【发表日期】

：

2016年4期

【关键词】

：

Lipid nanoparticles hydrophobic substitutes mucus barrier epithelium barrier

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Lipid nanoparticles(LNs)have been widely investigated in oral drug delivery,displaying dramatic advantages in colloidal stability,biocompability and scaling-up.However,how to further elevate the ability of LNs to conquer multiple barriers(ie.mucus and epithelium barrier)in the gastrointestinal(GI)tract is still challenging due to the contradictory requirement of NP surface properties in the two processes.

其他文献

生物启发型树状大分子:从纳米递送系统构筑到新型肽类药物设计

会议

Development of a Multi-Target Peptide for Potentiating Chemotherapy by Modulating Tumor Microenviron

会议

Multifunctional dextran sulfate-coated reconstituted high density lipoprotein by blocking SR-AI rece

会议

Tumor targeted nanoassemblies for paclitaxel delivery based on hydrophobically modified chitosan

会议

Inhalable andrographolide-β-cyclodextrin inclusion complexes for the treatment of bacterial pneumoni

Objective Andrographolide(AG)is an antibacterial and anti-inflammatory agent,extracted from a traditional Chinese medicine andrographis paniculata.AG Tablets and Pills are clinically applied for the t

会议

bacterial pneumoniaandrographolideβ-cyclodextrininclusion complexespulmonary

Preparation and characterization of safflower flavonoid extract Dripping pills and its transport mec

Kaempferol-3-O-rutinoside(K3R)andanhydrosafflor yellow B from safflower,have neuroprotective effect.In this study,we prepared pills from safflower flavonoids extracts and excipients by heating and mel

会议

Safflowerkaempferol-3-O-rutinosidepillsParkinson's diseaseCaco-2 cell m

Preparation and release behavior of sustained release desvenlafaxine succinate pellets

OBJECTIVE Our study aimed to prepare sustained-release desvenlafaxine succinate(DVS)pellets coated with aqueous ethylcellulose dispersion(Surelease(R))and to investigate their drug release behavior.

会议

Desvenlafaxine succinateEthylcellulose aqueous dispersionSustained-release pel

The Enantioseperation and Optical Stability with Ultron ES-CD Optical Column in Epotastine Besilate

会议

RGD conjugated liposome-hollow silica hybrid nanovehicles for targeted and controlled delivery of ar

Targeted delivery and controlled drug releasing are two strategies to enhance the anticancer effect of arsenic trioxide(ATO)which was hampered by its poor pharmacokinetics(PK)and dose-limited toxicity

会议

arsenic trioxidehollow mesoporous silica nanoparticlesliposomal shellArg-Gly-

Polyethylene-polyglutamine as a gene carrier delivering MDR1 siRNA to A549/DDP cells for reversal of

A major problem in cancer chemotherapy is the development of multidrug resistance(MDR)by tumour cells.In recent years,RNAi-based technology holds enormous potential beyond a laboratory to the clinic.R

会议

multidrug resistancesiRNA deliverycationic polymerMDR1cisplatin

Lipid nanovehicles with adjustable surface properties for overcoming multiple barriers simultaneousl

其他学术论文