【摘 要】
:
The first catalytic asymmetric isatin-involved Povarov reaction has been established.This method provides an unprecedented approach to access enantioenriched spiro[indolin-3,2-quinoline] scaffold with
【机 构】
:
School of Chemistry and Chemical Engineering,Jiangsu Normal University,Xuzhou 221116,China
【出 处】
:
The 24th International Society of Heterocyclic Chemistry Con
论文部分内容阅读
The first catalytic asymmetric isatin-involved Povarov reaction has been established.This method provides an unprecedented approach to access enantioenriched spiro[indolin-3,2-quinoline] scaffold with concomitant creation of two quaternary stereogenic centers in high yields and excellent stereoselectivities (all >99:1 dr, up to 97% ee).
其他文献
By using a Modular Reaction Sequence strategy, a novel multicomponent reaction of in situ generated 1-azadienes and 9-isocyanofluorene furnishing novel 2-(fluorenylidenimino)pyrrole chromophores was d
An N-nitroso moiety can be used for the activation of chloropyrimidines towards nucleophilic substitution reaction with amines.The subsequent treatment of obtained products with aq.H2SO4 can lead eith
An efficient Cu-catalyzed synthesis of quinazolines via the C-N formation reactions between N-H bonds of amidines and C(sp3)-H bonds adjacent to sulfur or nitrogen atom in the commonly used solvents,
The 2-alkynyl-alk-2-en-1-ones have been found to be powerful precursors for synthesis of various polysubstituted furans via the 1,3-dipole intermediate in the presence of transition metals,[1-4] we re
Recent studies have shown that pyrrolo[2,3-d]pyrimidine-based oligoarylenes exhibit valuable photoluminescent properties.[1] In view of the growing importance of highly efficient light-emitting materi
Carbodiimides (RN=C=NR) have proved, over the last 130 years, to be versatile reagents and they rank as one of the most important classes of sources of nitrogen in organic chemistry.This presentation
We realized the fabrication of a new kind of supramolecular organometallic gels with a discrete rhomboidal metallocycle as the main skeleton via hierarchical self-assembly.More importantly, by taking
The synthesis of cholaphanes by ring closing metathesis of O-allylderivatives of cholic acid relatives will be presented.[1] The same approach was applied to the synthesis of macrocyclic molecular rot
An unprecedented copper-catalyzed trifluoromethylation-initiated radical 1,2-aryl migration in α,α-diaryl allylic alcohols has been disclosed, which allowed access to a variety of α-aryl β-trifluorome
A systematic study on the biological activity of pyrrolopyrimidinesas epidermal growth factor receptor (EGFR) inhibitors has been performed.[1] This has led to severalcompounds showing low nanomolar a